Drug transport across the human placenta: review of placenta-on-a-chip and previous approaches
نویسندگان
چکیده
منابع مشابه
Nutrient transport across the placenta.
The placenta forms a selective barrier that functions to transport nutrients that are of critical use to the fetus. Nutrient transport across the placenta is regulated by many different active transporters found on the surface of both maternal and fetal facing membranes of the placenta. The presence of these transporters in the placenta has been implicated in the facilitation of nutrient diffus...
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Folate (B9) is an essential molecule for the development and maturation of cells. During gestation, it is extremely important to the growth and development of the nervous system. Systemic deficiencies of B9 during pregnancy cause neural tube defects (NTD) ranging from spina bifida to anencephaly. However, over supplementation of folate has been linked with the progression of cancer and therefor...
متن کاملRegulation of Nutrient Transport across the Placenta
Abnormal fetal growth, both growth restriction and overgrowth, is associated with perinatal complications and an increased risk of metabolic and cardiovascular disease later in life. Fetal growth is dependent on nutrient availability, which in turn is related to the capacity of the placenta to transport these nutrients. The activity of a range of nutrient transporters has been reported to be de...
متن کاملKinetic analysis of the transport of salicylic acid, a nonsteroidal anti-inflammatory drug, across human placenta.
The aim of this study was to develop a pharmacokinetic model to describe the transplacental transfer of drugs, based on the human placental perfusion study. The maternal and fetal sides of human placentas were perfused with salicylic acid together with antipyrine, a passive diffusion marker. The drug concentration in the placental tissue was determined at the end of perfusion. A compartment mod...
متن کاملTransport of persistent organic pollutants across the human placenta.
Prenatal life is the most sensitive stage of human development to environmental pollutants. Early exposure to persistent organic pollutants (POPs) may increase the risk of adverse health effects during childhood. The mechanisms of transference of POPs during pregnancy are still not well understood. The present study is aimed to investigate the transfer of POPs between mother and fetus. The conc...
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ژورنال
عنوان ژورنال: Interface Focus
سال: 2019
ISSN: 2042-8898,2042-8901
DOI: 10.1098/rsfs.2019.0031